Protein Details: Acid-sensing ion channel 1

Protein ID

ICDB_Pro_1159

Protein Name

Acid-sensing ion channel 1

Gene Name

asic1; accn2

Organism

Opsanus tau (Oyster toadfish) (Gadus tau)

Length

522 amino acids

AlphaFoldDB

AF--F1-model_v4.pdb

Function

Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions; but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.

Sequence

MDLKADSEDVDYKQPAPIEDFASRSTLHGISHMFTYERVCIKRTLWILFFLGSVGALALVCVDRVQFYFQYPHVTKLDEVAAPLMTFPAVTFCNLNSFRFSRVTRNDLYHAGELXALLNGRYEIRDTHLVEENVLEILKERANFDNYKPRPFNMREFYDRTGHDIKDMLLSCYYRGVECNAENFKVIFTRYGKCYTFNSGKDGRPLLLTMKGGMGNGLELMLDIQQDEYLPVWGETDETSFEAGIKVQIHTQSEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCKAAPMDSDFFSTYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVERDNDYCVCKTPCNLTRFGKEMSFVKIPSKASAKYLAKKFXKTEQYIADNILVLDIYFDALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASILTILELFDYLYEVLKYKLCRCVKKKHKGRGNKDRGAVLSLDDVKRHAPCENLRTPSTYPGNMLPHHPGQGNFEDFTC

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 71: "Important for channel gating"; SITE 79: "Important for channel desensitizing"; SITE 287: "Important for channel gating"

Disease

Location

DOI ID

10.1074/jbc.m304441200